We examine the relationship between monetary conditions and global stock returns. Previous studies established that U.S. stock returns during expansive U.S. monetary periods are significantly higher than returns during restrictive periods. We found that this pattern prevails in non-U.S. markets; furthermore, the pattern exists relative to both local and U.S. monetary conditions. By examining several investment strategies, we show that investors could have improved portfolio performance in the period studied by using both U.S. and local monetary conditions to guide their portfolio allocations. Using monetary conditions to determine portfolio composition would have been consistently beneficial throughout the past 30 years.